The washboard and frottoir (from Cajun French "frotter", to rub) are used as a percussion instrument, employing the ribbed metal surface of the cleaning device as a rhythm instrument. As traditionally used in jazz, zydeco, skiffle, jug band, and old-time music, the washboard remained in its wooden frame and is played primarily by tapping, but also scraping the washboard with thimbles. Often the washboard has additional traps, such as a wood block, a cowbell, and even small cymbals. Conversely, the frottoir (zydeco rubboard) dispenses with the frame and consists simply of the metal ribbing hung around the neck. It is played primarily with spoon handles or bottle openers in a combination of strumming, scratching, tapping and rolling. The frottoir or vest frottoir is played as a stroked percussion instrument, often in a band with a drummer, while the washboard generally is a replacement for drums. In Zydeco bands, the frottoir is usually played with bottle openers, to make a louder sound. It tends to play counter-rhythms to the drummer. In a jug band, the washboard can also be stroked with a single whisk broom and functions as the drums for the band, playing only on the back-beat for most songs, a substitute for a snare drum. In a four-beat measure, the washboard will stroke on the 2-beat and the 4-beat. Its best sound is achieved using a single steel-wire snare-brush or whisk broom. However, in a jazz setting, the washboard can also be played with thimbles on all fingers, tapping out much more complex rhythms, as in The Washboard Rhythm Kings, a full-sized band, and Newman Taylor Baker.

There are three general ways of deploying the washboard for use as an instrument. The first, mainly used by American players like Washboard Chaz of the Washboard Chaz Blues Trio and Ralf Reynolds of the Reynolds Brothers Rhythm Rascals, is to drape it vertically down the chest. The second, used by European players like David Langlois of the Blue Vipers of Brooklyn, Ben Turner of Piedmont Bluz, and Stephane Seva of Paris Washboard, is to hold it horizontally across the lap, or, for more complex setups, to mount it horizontally on a purpose-built stand. The third (and least common) method, used by Washboard Sam, Súle Greg Wilson of the Carolina Chocolate Drops and Sankofa Strings, and Deryck Guyler, is to hold it in a perpendicular orientation between the legs while seated, so that both sides of the board might be played at the same time.

There is a Polish traditional jazz festival and music award named "Złota Tarka" (Golden Washboard). Washboards, called "zatulas", are also occasionally used in Ukrainian folk music.